Genetics play a fundamental role in determining many aspects of our health, and prostate wellness is no exception. While lifestyle choices such as diet, exercise, and preventive care remain important, a man’s genetic makeup can significantly influence his risk of developing various prostate conditions, including prostate cancer and benign prostatic hyperplasia (BPH). At 1Prostate Center in Manhattan and Queens, Dr. David Shusterman helps patients understand how family history and inherited genetic traits contribute to prostate health and how they can proactively manage their risk.
For men with a family history of prostate disease, the importance of early screening and proactive monitoring cannot be overstated. Inherited genetic mutations—especially in genes like BRCA1, BRCA2, and HOXB13—have been linked to higher rates of aggressive prostate cancer. Men who have first-degree relatives, such as a father or brother, diagnosed with prostate cancer are more than twice as likely to develop the condition themselves. This is particularly relevant for those seeking prostate cancer treatment in Midtown Manhattan, where early detection and precision treatment options can be life-saving.
Understanding Hereditary Risk Factors
Genetic risk for prostate conditions often stems from specific inherited mutations that affect cell growth and DNA repair. In families with a strong history of cancer, particularly prostate, breast, or ovarian cancer, the presence of mutations in BRCA1 and BRCA2 genes can dramatically increase the risk of developing aggressive prostate cancer. These mutations disrupt the body’s ability to fix damaged DNA, allowing cancerous cells to multiply more easily. At 1Prostate Center, Dr. Shusterman incorporates genetic counseling and testing for patients with a known family history or those presenting with early-onset or aggressive disease.
In addition to BRCA mutations, the HOXB13 gene has also been identified as a strong risk factor. While less common, mutations in this gene have been linked to hereditary prostate cancer, particularly in families with multiple affected members. Understanding whether you carry any of these gene mutations can guide decisions about screening frequency and treatment choices. Dr. Shusterman often recommends PSA testing at a younger age for patients with a strong genetic predisposition, and he provides comprehensive management at his urology clinic in NYC.
Not all genetic risk is inherited through identifiable mutations, however. Researchers have discovered over 100 genetic variations, called single nucleotide polymorphisms (SNPs), that can subtly increase the risk of prostate disease. These don’t cause cancer on their own but may contribute to overall risk when combined with other genetic and environmental factors. Men searching for a urologist near me in Midtown Manhattan can benefit from the advanced diagnostic approach available at 1Prostate Center, where risk is assessed through both clinical and genetic lenses.
Enlarged Prostate and Genetics
While most genetic discussions focus on prostate cancer, benign prostatic hyperplasia also has a hereditary component. BPH, the non-cancerous enlargement of the prostate gland, becomes increasingly common with age and can cause significant urinary symptoms such as frequency, urgency, weak stream, and nighttime urination. Studies show that men with a family history of BPH are significantly more likely to develop the condition themselves, often at a younger age.
At 1Prostate Center, patients dealing with urinary symptoms are carefully evaluated for both BPH and potential genetic contributors. Dr. Shusterman offers enlarged prostate treatment in Midtown Manhattan using the most advanced minimally invasive techniques available, including UroLift and Rezum therapy. These treatments aim to relieve urinary obstruction while preserving sexual function. Identifying a hereditary pattern allows Dr. Shusterman to recommend earlier screenings and more proactive management strategies for at-risk individuals.
Because urinary symptoms can overlap with other conditions such as urinary incontinence or even kidney stones, patients benefit from a full evaluation. For those in need of urinary incontinence treatment or kidney stones treatment in Midtown Manhattan, Dr. Shusterman delivers integrated care that addresses the underlying cause while alleviating discomfort and restoring function.
Prostate Cancer and Genetic Testing
Genetic testing for prostate cancer risk is becoming more common and more accessible. It can be especially helpful for men with a strong family history or early-onset disease. At 1Prostate Center, Dr. Shusterman may recommend genetic screening for men who have multiple family members affected by prostate or other related cancers, or for those diagnosed with aggressive prostate cancer at a younger age. This information can be used to inform not only the patient’s care, but also the health management of male relatives who may share the same genetic markers.
Knowing your genetic status can also influence treatment decisions. Men with BRCA mutations may be candidates for specific therapies, such as PARP inhibitors, which target cancer cells with defective DNA repair mechanisms. Additionally, patients with inherited risks often benefit from more frequent monitoring, including advanced imaging and molecular testing, to ensure any changes are detected as early as possible.
As one of the best urologists for prostate cancer in Midtown Manhattan, Dr. Shusterman is committed to precision medicine. He believes that every patient deserves a treatment plan that takes into account not only clinical findings, but also family history and genetic background. By understanding the role of genetics in prostate health, patients can take proactive steps toward prevention and early intervention.
Taking Action Through Personalized Care
At 1Prostate Center, personalized care begins with awareness. Dr. Shusterman encourages all men—especially those over 50 or with a family history of prostate conditions—to undergo routine screenings and speak openly about their medical history. Even if symptoms are mild or absent, regular evaluations can help identify problems early and reduce the risk of complications.
Whether you’re concerned about prostate cancer, experiencing urinary issues, or simply want to stay ahead of your health, Dr. Shusterman offers complete support in both Manhattan and Queens. From prostate exams and PSA testing to erectile dysfunction treatment in Midtown Manhattan and beyond, every service is tailored to your individual risk and lifestyle.
If you’re looking for a urology doctor in NYC or a urology clinic in NYC that understands the connection between genetics and prostate health, 1Prostate Center offers the expertise and technology you need. Schedule a consultation today and take the next step in understanding and protecting your prostate health for years to come.
Resources
Pritchard, C. C., et al. (2016). Inherited DNA-Repair Gene Mutations in Men with Metastatic Prostate Cancer. New England Journal of Medicine.
Eeles, R. A., et al. (2013). Identification of 23 New Prostate Cancer Susceptibility Loci. Nature Genetics.
Carter, H. B., et al. (2013). Prostate Cancer Screening in Men with a Family History of Prostate Cancer. Journal of Urology.
